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Current Research Projects


We have been studying the effects of Alkontrol-herbal for nearly 20 years for its ability to reduce alcohol consumption. We conducted a NIH funded clinical trial of Alkontrol-herbal versus placebo. 
Before the study started, the participants drank an average of 35 alcoholic beverages per week and abstained from drinking, on average, 1.8 consecutive days. After only 3 weeks of treatment with Alkontrol-herbal, the number of drinks dropped to ~10 per week (Figure 1) and the participants extended the number of consecutive NO drinking days to 4 in a row (Figure 2). 
Participants wore a wrist actigraphy watch to record their sleep/wake activity and they could press a marker button whenever they had a drink or took the double-blind medication. The analysis of these data revealed that the pattern of drinking was affected by Alkontrol-herbal. Figure 3 shows the sleep/wake activity and actual drinks consumed (arrows) over a three-day weekend by a typical participant at Baseline and during the 4th week of treatment with Kudzu. Note that the number of binge drinking days was decreased and the number of drinks per binge was also smaller. The red dots represent the times when the Kudzu dose was taken. These positive outcomes occurred with no reported side effects. A full report of all study results was published in a scientific journal*.

To learn more, visit the study page.

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*Lukas et al., 2012; Psychopharmacology 226(1):65-73.


Figure 3.

Do you live in the Boston area? Are you interested in participating in clinical research for Alkontrol-herbal

HLXL (Completed Phase II Trial for Osteoarthritis)

A classical Chinese herbal formula, Huo Luo Xiao Ling Dan, is commonly used in traditional Chinese herbal medicine to treat “Bi syndrome”, as arthritis is known. It consists of four herbs, Ru Xiang (Boswellia carterii Birdw.), Mo Yao (Commiphora myrrha Engl.), Dang Gui (Angelica sinensis (Oliv.) Diels) and Dan Shen (Salvia miltiorrhiza Bge.). Its main actions are to promote circulation, alleviate pain and reduce swelling.

We have substantially improved classical Huo Luo Xiao Ling Dan according to the principles of Chinese herbology by adding eight other herbs that have shown benefits for arthritis patients in clinic (and eliminating Mo Yao, which has the same function as Ru Xiang). These eight new herbs traditionally have also been used for “Bi syndrome” to promote blood circulation and relieve pain.

HLXL has currently completed a Phase II clinical trial at Kernan Hospital of the University of Maryland School of Medicine. NPI is the exclusive provider of HLXL used in the Phase II clinical trial. 

For more details, please visit, the official registry of federally and privately supported clinical trials conducted in the US and around the world. Information about the HLXL trial can be found HERE.


The time course of the anti-hyperalgesic effects of four different dosages of HLXL given daily for 7 days, starting one day prior to CFA. PWL of CFA-inflamed hind paw was measured immediately before (I) and 1 hour after (II) herbal administration. Values are mean ± SE (n = 8/group). *p < 0.05, **p < 0.01 compared to the vehicle control.


Other Current Research Studies

3.4   Cancer Care Complement Series

NPI is developing a herbal supplement that enhances patients’ immunological functions before and after chemo- or radio- therapies.

3.5   Cosmetics Formula

NPI is developing a unique herbal formula to help women to maintain the youth of their skin.  This formula can also be used together with Thermo-Rock synergistically.

3.6   Diabetics Formula

NPI is developing an herbal formula to improve the health of the diabetic population.

3.7   Heart Health Series

NPI has developed a safe herbal supplement, CholesterOff, that can modulate blood cholesterol level. It is undergoing clinical trial in human subjects in Asia.

3.8   Tri-isoflavones for Postmenopausal Symptoms

NPI is developing a unique combination of three isoflavones (phytoestrogens) that is the best studied herbal remedy for post-menopausal symptoms including bone loss.

3.9   Weight Loss Formula

NPI is developing a safe herbal product that promotes weight reduction. US patent is pending.

3.10 Other Early Stage Programs

There are several other exciting early stage products on which NPI is currently working.  Visit our website often for up-to-date information.

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